Showing posts from December, 2014

DREADDs in newborn neurons

I occasionally receive queries regarding the use of retrovirally delivered DREADDs to newly born neurons in dentate gyrus.  Here is a nice use of this technology along with optogenetics in hippocampus in Neuron.

Using intersectional genetics and DREADDs to deconstruct breathing

Very nice paper out in Cell Reports on this topic.

A note about authorship, MTAs, IP and other matters related to DREADDs


As should be evident to all (though I still get queries about this) DREADD technology is open source with no associated intellectual property (IP)-encumbrances. There is no need for an MTA to use/obtain the technology*.

The technology is not patented and is given freely to the scientific community without restrictions as to use.  Future enhancements also will never be patented by me.

This means that if you make a 'non-obvious enhancement' you conceivably could patent it.

What this means is that you can obtain the *cDNAs from ADDGENE, *mice from JAX and viruses from UNC and use them for whatever purposes you desire without permission from my lab.  This includes pharma/biotech.


As a general rule not include me or any member of my lab as authors on your papers using DREADD technology simply because we shared a reagent with you or offered you helpful advice (e.g. how to dissolve CNO).  If you are unsure, please discuss with us before you submit the paper (or send …