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Showing posts from March, 2016

CELL: Robust chemogenetic modulation of Systemic Insulin Sensitivity via Myostatin Expression in Brown Adipose Tissue

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A quite amazing paper has appeared recently here.
Of note is the replication of a technology reported previously of DREADD-assisted neuronal activity mapping.

NATURE: DREADDs to deconstruct predator odor neurons

YUSTE LAB: More evidence for in vivo silencing via DREADDS

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Nice paper just published.
Key data below:

KOR-DREADD and ETOH

Another paper showing the utility of both RETRO-DREADD and KOR-DREADD technology.

CELL: DREADDs to Control Whole-Body Glucose Metabolism via VMH

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Pretty interesting paper published a couple of weeks back in Cell; key data below:



Visual step-by-step guide to dissolve CNO

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That's "Bryan" not "Brian"

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From an eLife paper where DREADDs were used extensively:

"For hM4D(Gi) experiments, we infected V1 of P30-60 PV-Cre mice or wild-type littermates with an AAV9-hSyn-DIO-HA-hM4D(Gi)-IRES-mCitrine virus (UNC viral core – generated by Dr. Brian Roth’s laboratory)"

There are plenty of Brian and Bryan out there and here is a photo of 3 at once (Bryan Roth, Brian Kobilka [Nobel 2012], Brian Shoichet)




NATURE COMMUNICATIONS: DREADDs outside the CNS

Nice paper here using Gq-DREADD and many other approaches to deconstruct Gq signaling in various adipose tissues.

Decreasing cortical activity rescues Shank3B−/− phenotype by hM4Di

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Interesting paper in Nature Neuroscience.

Data below:

NATURE NEUROSCIENCE: DREADDs and optogenetics deconstruct reward value of sugar