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Showing posts from April, 2015

A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior

Now on-line at Neuron . The constructs will be available soon from ADDGENE   without MTA. Viruses will be available next week (May 3) from UNC . This DREADD is activated by salvinorin B which may be purchased from Cayman  or from S cott Wyer at Apple Pharms at a great discount.

Using DREADDs to identify cells involved in mediating aggression

Interesting paper in Cell Reports on this topic.

Using DREADDs to deconstruct contribution of astrocytes to feeding

Astrocytes Control Food Intake by Inhibiting AGRP Neuron Activity via Adenosine A 1  Receptors

PRESTO-TANGO: An open-source GPCR-ome resource for validating selectivity of chemogenetic actuators

Here is a paper just published which provides for an open-source resource for screening the druggable human GPCR-ome for off-target actions of chemogenetic chemical actuators.  The cDNAs will soon be available from ADDGENE and are available until then from the Roth lab.

Tet-tagged DREADDs

A cool paper using this technology to deconstruct Neuronal ensembles sufficient for recovery sleep and the sedative actions of α 2  adrenergic agonists

Using DREADDs to deconstruct pathways essential for treating neuropsychiatric disease

Nice paper in PNAS by Caron's lab.