Showing posts from April, 2016

CURRENT BIOLOGY: The reactivation by DREADDs reproduces sex-specific aggression to ESP1

Pretty amazing movie here.

Exocrine gland-secreting peptide 1 (ESP1) released into male tear fluids is a male pheromone that stimulates sexually receptive behavior in female mice via the vomeronasal sensory system. ESP1 also induces c-Fos expression in male brain regions distinct from those in females. However, behavior in males following ESP1 exposure has not been examined. In the present study, we show that ESP1, in conjunction with unfamiliar male urine, enhances male aggression via the specific vomeronasal receptor V2Rp5. In addition, male mice that secrete ESP1 but lack V2Rp5 exhibit a lower level of aggressiveness than do mice that express V2Rp5. These results suggest that ESP1 not only acts as a male pheromone in both sexes but also serves as an auto-stimulatory factor that enhances male aggressiveness by self-exposure. Finally, re-activation of ESP1-induced c-Fos-positive neurons by using the designer receptor exclusively activated by designer drug (DREADD) approach resulted in…

Nature Neuro: Silencing spinal interneurons inhibits immune suppressive autonomic reflexes caused by spinal cord injury

Spinal cord injury (SCI) at high spinal levels (e.g., above thoracic level 5) causes systemic immune suppression; however, the underlying mechanisms are unknown. Here we show that profound plasticity develops within spinal autonomic circuitry below the injury, creating a sympathetic anti-inflammatory reflex, and that chemogenetic silencing of this reflex circuitry blocks post-SCI immune suppression. These data provide new insights and potential therapeutic options for limiting the devastating consequences of post-traumatic autonomic hyperreflexia and post-injury immune suppression.

DREADD-induced inactivation of the lateral orbitofrontal cortex increases drinking in ethanol-dependent but not non-dependent mice

I'm seeing a lot of work with DREADDs among researchers in the ETOH field.  Here's an interesting paper

Pivotal role of a dorsolateral corticospinal pathway in mediating spontaneous recovery after SCI

Nice paper combining chemo- and optogenetics.

Promoter-Specific Effects of DREADD Modulation on Hippocampal Synaptic Plasticity and Memory Formation

Interesting and carefully-controlled study recently published in J Neuroscience.

DREADD-induced Activation of Subfornical Organ Neurons Stimulates Thirst and Salt Appetite