Informative and helpful review on DREADDs
Can be found here.
Posts
How does Salvia exert it's actions in humans--Kappa Receptor!
Though we discovered this some time ago , there has been lingering controversy regarding it's mechanism of action in humans. Here is a controlled study consistent with k-opioid being essential target.
NEURON PRIMER ON DREADDS: essential and (hopefully) useful information for users
On-line here . A fair amount of time was spent on this to make sure key issues were addressed --especially those which may not be obvious to those who do not study GPCRs. BTW: DREADDs are engineered GPCRs......
TOCRIS NOW HAS ALL VALIDATED DREADD LIGANDS AVAILABLE
Link is here . My lab receives no proceeds from the sales of DREADD ligands and they are available to anyone without encumbrances (IP or otherwise).
NEW DREADD: Gq/11 without arrestin activation
This will be useful for determining how and to what extent canonical (G protein) vs non-canonical (arrestin) singaling is essential for the actions of a particular biological/physiological phenomenon.
Use of M1 -DREADD to probe learning and memory
A nice paper just published using the M1-DREADD which like M3 is Gq coupled to interrogate learning and memory. As predicted M1 behaves similarly to M3.