DREADDs, fast-spiking interneurons and animal models of schizophrenia

I get periodic queries as to whether/if hM4D can inhibit the firing of fast-spiking interneurons.  The answer is, apparently, yes. 


The authors go on to make connections with circuitry dysregulation posited to occur in schizophrenia...

Comments

  1. zendudestDecember 1, 2014 at 6:26 AM

    And it is possible to excite parvalbumin neurons as well with hM3Dq

    http://jp.physoc.org/content/early/2014/05/29/jphysiol.2014.275453.abstract

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