DREADDs, fast-spiking interneurons and animal models of schizophrenia

I get periodic queries as to whether/if hM4D can inhibit the firing of fast-spiking interneurons.  The answer is, apparently, yes. 

The authors go on to make connections with circuitry dysregulation posited to occur in schizophrenia...


  1. And it is possible to excite parvalbumin neurons as well with hM3Dq



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