DREADDs, fast-spiking interneurons and animal models of schizophrenia

I get periodic queries as to whether/if hM4D can inhibit the firing of fast-spiking interneurons.  The answer is, apparently, yes. 


The authors go on to make connections with circuitry dysregulation posited to occur in schizophrenia...

Comments

  1. zendudestDecember 1, 2014 at 6:26 AM

    And it is possible to excite parvalbumin neurons as well with hM3Dq

    http://jp.physoc.org/content/early/2014/05/29/jphysiol.2014.275453.abstract

    ReplyDelete

Post a Comment

Popular posts from this blog

CNO in drinking water

We frequently get requests regarding protocols for putting CNO in the drinking water for long-term studies. Here is our protocol: 1. Dissolve the CNO in a small volume of DMSO 2. Diluted the dissolved CNO in drinking water (e.g., 5mg/200ml) 3. Give mice with CNO drinking water  and protect from light using foil-wrapped bottles 4. The mice will receive 5mg/kg/day CNO (assume that mice weight 30g and consume 6ml water per day) 5. Prepare fresh daily. 6. A small amount of saccharine in the drinking water will mask the slightly bitter taste of CNO
Read more