Retro-DREADDs for pathway mapping and modulation in primates

A very nice 'proof-of-concept' study to show feasibility of using Retro-DREADD technology in primates as shown in Figure 1 from paper


"The aim of the inclusion of DREADDs in the AAV5 is to test the feasibility of DREADD expression on the specific prefrontal neurons in the macaque brain for future pharmacogenetic manipulation studies. Although we did not test the behavioral and neuronal effects of CNO administration in this study, the observation of mCherry-positive neurons highly likely indicates DREADD expression in our double infection system. "

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