DREADDs to decostruct visceral pain

"The activity of neurons in pancreatitis-related pain centers was pharmacogenetically modulated by DREADDs, selectively and cell type-specifically expressed in target neurons using AAV-mediated gene transfer. Pharmacogenetic inhibition of PVT, but not PAG neurons attenuated visceral pain, and induced an activation of the descending inhibitory pain pathway. Activation of glutamatergic principle neurons in the mPFC, but not inhibitory neurons, also reversed visceral nociception."

Abbreviations:  the paraventricular nucleus of the thalamus (PVT), the periaqueductal grey (PAG) 

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