Reversing (certain) autism deficits using DREADDs targeting Oxytocin neurons

Now here is a pretty amazing paper which has destroyed many of my objections related to the role of oxytocin and oxytocin neurons in mediating social behavior in mice (and potential for human therapeutics).

Paper just published in Science Translational Medicine....interesting ....

Also nice use of oxytocin promotor for cell-type specific expression of hM3Dq

Comments

Post a Comment

Popular posts from this blog

CNO in drinking water

We frequently get requests regarding protocols for putting CNO in the drinking water for long-term studies. Here is our protocol: 1. Dissolve the CNO in a small volume of DMSO 2. Diluted the dissolved CNO in drinking water (e.g., 5mg/200ml) 3. Give mice with CNO drinking water  and protect from light using foil-wrapped bottles 4. The mice will receive 5mg/kg/day CNO (assume that mice weight 30g and consume 6ml water per day) 5. Prepare fresh daily. 6. A small amount of saccharine in the drinking water will mask the slightly bitter taste of CNO
Read more