Use of AAV for therapy of human CNS diseases: relevance for use of DREADDs in humans

The recent posts on the use of DREADDs in primates and novel lentiviral approaches in primate brain has raised the issue of the suitability of virally-mediated transduction of human neurons for delivery of various cargos (including DREADDs). shows many ongoing/completed trials of AAV-based gene delivery for a variety of CNS diseases in humans indicating that this is certainly feasible.


Popular posts from this blog

How best to dissolve CNO depends on what it is soluble in (and that depends on the particular polymorph)