Use of AAV for therapy of human CNS diseases: relevance for use of DREADDs in humans

The recent posts on the use of DREADDs in primates and novel lentiviral approaches in primate brain has raised the issue of the suitability of virally-mediated transduction of human neurons for delivery of various cargos (including DREADDs).

Clinicaltrials.gov shows many ongoing/completed trials of AAV-based gene delivery for a variety of CNS diseases in humans indicating that this is certainly feasible.

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